Archives of Biological Sciences 2013 Volume 65, Issue 4, Pages: 1435-1445
https://doi.org/10.2298/ABS1304435H
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The protective effect of vitamin E against genotoxicity of lead acetate intraperitoneal administration in male rat
Hamadouche Nadia Ait (University Es-senia, Department of Biology, Laboratory of Experimental Biotoxicology, Biodepollution and Phytoremediation, Oran, Algeria)
Sadi Nesrine (University Es-senia, Department of Biology, Laboratory of Experimental Biotoxicology, Biodepollution and Phytoremediation, Oran, Algeria)
Kharoubi Omar (University Es-senia, Department of Biology, Laboratory of Experimental Biotoxicology, Biodepollution and Phytoremediation, Oran, Algeria)
Slimani Miloud (University Dr Moulay Tahar, Department of Biology, Faculty of Science and Technology, Saida, Algeria)
Aoues Abdelkader (University Es-senia, Department of Biology, Laboratory of Experimental Biotoxicology, Biodepollution and Phytoremediation, Oran, Algeria)
Lead is an industrial pollutant that may exert specific toxic effects on male
mammals. The aim of this study was to investigate further the protective
effects of vitamin E on lead acetate (Pb)-induced reproductive toxicities and
genotoxic effects on male rats. Sexually mature male Wistar rats (weighing
120-160 g) were given Pb (20 mg/Kg) and vitamin E (600 mg/kg/rat) orally for
20 days. The sperm count, sperm motility, sperm morphology, chromosomal
aberrations, FSH, LH and testosterone levels, and histopathological changes
in the testes of the rats were investigated after 20 days. Results revealed a
statistically significant (p<0.01) increase in the number of abnormal sperm
in treated animals. Lead acetate increased the percentage of chromosomal
abnormalities. A significant decrease in LH, FSH and testosterone were
observed in the treated group compared to the control. Pathological
examination of testicular tissues showed degenerative changes of
spermatogonia and spermatocytes to advanced degeneration and vacuolation.
Lead acetate can be considered to have an environmental genotoxic and
cytotoxic effect in the male rat and may contribute to a reduction of
fertility. Vitamin E administration could reduce the genotoxic effect of lead
in somatic and germ cells.
This article has been retracted. Link to the retraction 10.2298/ABS150615078E
Keywords: lead, genotoxicity, chromosome aberration, vitamin E