Archives of Biological Sciences 2012 Volume 64, Issue 3, Pages: 843-850
https://doi.org/10.2298/ABS1203843S
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Combined treatment with ribavirin and tiazofurin attenuates response of glial cells in experimental autoimmune encephalomyelitis
Savić Danijela (Department for Neurobiology, Institute for Biological Research “Siniša Stanković”, Belgrade)
Lavrnja Irena 
(Department for Neurobiology, Institute for Biological Research “Siniša Stanković”, Belgrade)
Dacić Sanja (Institute for Physiology and Biochemistry, Faculty of Biology, Belgrade)
Bjelobaba Ivana (Department for Neurobiology, Institute for Biological Research “Siniša Stanković”, Belgrade)
Nedeljković Nadežda (Institute for Physiology and Biochemistry, Faculty of Biology, Belgrade)
Peković Sanja (Department for Neurobiology, Institute for Biological Research “Siniša Stanković”, Belgrade)
Stojiljković Mirjana (Department for Neurobiology, Institute for Biological Research “Siniša Stanković”, Belgrade)
Experimental autoimmune encephalomyelitis (EAE) is an animal model of
multiple sclerosis (MS), a human inflammatory and demyelinating disease.
Microglia and astrocytes are glial cells of the central nervous system (CNS)
that play a dual role in MS and EAE pathology. The aim of this study was to
examine the effect of combined treatment with two nucleoside analogues,
ribavirin and tiazofurin, on microglia and astrocytes in actively induced
EAE. Therapeutic treatment with a combination of these two nucleoside
analogues reduced disease severity, mononuclear cell infiltration and
demyelination. The obtained histological results indicate that ribavirin and
tiazofurin changed activated microglia into an inactive type and attenuated
astrocyte reactivity at the end of the treatment period. Since reduction of
reactive microgliosis and astrogliosis correlated with EAE suppression, the
present study also suggests that the obtained beneficial effect of ribavirin
and tiazofurin could be a consequence of their action inside as well as
outside the CNS.
Keywords: Experimental autoimmune encephalomyelitis, glial cells, ribavirin, tiazofurin
Acknowledgments. This work was supported by the Serbian
Ministry of Education and Science, Project No: III41014.