doiSerbia

Glutathione protects liver and kidney tissue from cadmium- and lead-provoked lipid peroxidation

Jovanović Jasmina M. (Department of Chemistry, Faculty of Science and Mathematics, Niš)
Nikolić Ružica S. (Department of Chemistry, Faculty of Science and Mathematics, Niš)
Kocić Gordana M. (Faculty of Medicine, Niš)
Krstić Nenad S. (Department of Chemistry, Faculty of Science and Mathematics, Niš)
Krsmanović Milena M. (Department of Chemistry, Faculty of Science and Mathematics, Niš)

Cd and Pb represent a serious ecological problem due to their soluble nature, their mobility and ability to accumulate in the soil. The exposure to these heavy metals can originate from different sources (drinking water, food, air), and they can make their way into the human body through the respiratory and digestive system. We investigated the effects of glutathione on Cd and Pb accumulation and lipid peroxidation effects in the liver and kidneys of heavy metal intoxicated rats. The content of the marker of lipid peroxidation - malondialdehyde was increased several fold the in tissues of exposed animals, the effects being more pronounced in liver. The treatment of intoxicated animals with glutathione drastically suppressed lipid peroxidation. Our results imply that the application of glutathione may have protective role in heavy metal intoxication by inhibiting lipid peroxidation. However, precaution should be made when it comes to Cd, since it seems that glutathione promoted Cd accumulation in the liver.

Keywords: cadmium, lead, glutathione, lipid peroxidation, malondialdehyde