doiSerbia

Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives

Vaghasia S.J. (Department of Chemistry, Saurashtra University, Rajkot, India)
Shah V.H. (Department of Chemistry, Saurashtra University, Rajkot, India)

The synthesis of thiazolo[5,4-d]pyrimidines can be achieved from different 5- thiazolidinones, 2-butyl-1H-imidazole-5-carbaldehyde and thiourea using microwave irradiation within 5 min. The structures of the products were supported by FTIR, PMR and mass spectral data. The in vitro antimicrobial activity of the synthesized thiazolo[5,4-d]pyrimidines 1a-j, having substituents at the 1- and 3-positions, were determined by the cup-plate method against several standard strains chosen to define the spectrum and potency of the new compounds. The antimicrobial activities of the thiazolo[5,4-d]pyrimidines 1a-j are compared with those of known chosen standard drugs, viz. ampicillin, chloramphenicol, ciprofloxacin, norfloxacin and griseofulvin. .

Keywords: microwave irradiation, thiazolo[5,4-d]pyrimidines, antimicrobial activity