Veterinarski glasnik 2023 Volume 77, Issue 2, Pages: 164-175
https://doi.org/10.2298/VETGL230710008K
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Selected hematology ratios in cats with non-septic effusions highly suspected of feline infectious peritonitis
Kopilović Aleksandar (Small Animal Veterinary Practice “ZooHome”, Belgrade, Serbia)
Gvozdić Dragan 
(University of Belgrade, Faculty of Veterinary Medicine, Department of Pathophysiology, Belgrade, Serbia)
Radaković Milena (University of Belgrade, Faculty of Veterinary Medicine, Department of Pathophysiology, Belgrade, Serbia)
Spariosu Kristina (University of Belgrade, Faculty of Veterinary Medicine, Department of Pathophysiology, Belgrade, Serbia)
Andrić Nenad (University of Belgrade, Faculty of Veterinary Medicine, Department of Pathophysiology, Belgrade, Serbia)
Francuski-Andrić Jelena (University of Belgrade, Faculty of Veterinary Medicine, Department of Pathophysiology, Belgrade, Serbia), jelenaf@vet.bg.ac.rs
In veterinary medicine, knowledge about hematologic ratios
(neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR)
and mean platelet volume-to-platelet ratio (MPV/PLT)) is limited,
particularly in cats. While the roles of these ratios have been proven in
oncology, systemic inflammation with or without systemic inflammatory
response syndrome (SIRS), and sepsis, information is lacking about their
alterations in non-septic effusions, like feline infectious peritonitis
(FIP). This study aimed to describe whether NLR, PLR, and MPV/PLT were
changed and whether they correlated with routine hematologic and biochemical
parameters in 16 cats with non-septic effusions, highly suspected to be the
effusive form of FIP without SIRS, compared to nine clinically healthy cats.
The NLR was calculated as the absolute count of neutrophils divided by the
absolute count of lymphocytes, PLR by calculating the absolute platelet
divided by the absolute lymphocyte count, and MPV/PLT by dividing mean
platelet volume by absolute platelet count. The NLR, MPV, and MPV/PLT
ratios were higher in cats with non-septic effusions suspected to be FIP,
but PLR did not differ, when compared to healthy cats. Correlation analysis
did not show any association between the selected ratios and hematological
and biochemical parameters. In the absence of leukocytosis, increased NLR
could help us to confirm the presence of systemic inflammation in cats with
non-septic effusions indicative of FIP. However, a high MPV/PLT ratio should
be interpreted with caution, especially in cats.
Keywords: inflammation, mean platelet volume-to-platelet ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio
Project of the Ministry of Science, Technological Development and Innovation, Republic of Serbia, Grant no. 451-03-47/2023-01/200143
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